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Published 2011-09-20 Published on SciPeople2011-10-01 18:26:52 JournalEuropean Journal of Medicinal Chemistry

Synthesis, antifungal activity and QSAR study of 2-arylhydroxynitroindoles
Kokurkina G.V., Dutov M.D., Shevelev S.A., Popkov S.V., Zakharov A.V., Poroikov V.V. / Vladimir Poroikov
Eur. J. Med. Chem., 2011, 46 (9), 4374-4382.
Abstract A series of 2-arylhydroxynitroindoles were prepared and tested for antifungal activity in vitro. The preliminary bioassays indicated that some compounds are comparable to the commercial fungicide (triadimefon). To further explore the structureeactivity relationships, the data set of the seventeen structures and their quantitative values of antifungal activities were used for QSAR modeling. Based on the obtained QSAR models four new chemical compounds were designed, synthesized and tested in fungicidal assays. Reasonable correspondence between the experimental and predicted values of antifungal activity was observed.


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