Татьяна Борисовна Тихонова

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Publications

Common binding site for externally and internally applied AMPA receptor channel blockers.

Tikhonova TB, Tikhonov DB, Magazanik LG
Adamantane derivative IEM-1676 (Ad-N+H2-(CH2)5-N+Me3) causes open-channel block of Ca2+ permeable AMPA receptors when applied externally, but internal application results in both closed- and open-channel block. The relationships between blocking action of externally and internally applied...
J Mol Neurosci. 39(1-2): 169-74 (2009)
→ glutamate receptors   → permeation   → gating   → channel block  

Organic blockers escape from trapping in the AMPA receptor channels by leaking into the cytoplasm

Tikhonova TB, Barygin OI, Gmiro VE, Tikhonov DB, Magazanik LG
The voltage-dependent block of AMPA receptor (AMPAR) channels by a series of dicationic compounds was studied on native GluR2-lacking receptors of striatal giant interneurons isolated from rat brain slices. The dicationic derivatives of adamantane, dimethyladamantane, diphenyl, and...
Neuropharmacology 54(4): 653-64 (2008)
→ AMPA receptor   → permeation   → channel gating   → channel block  

Mechanisms of blockade of glutamate receptors channels: the significance for structural and physiological investigations.

Magazanik LG, Tikhonov DB, Tikhonova TB, Lukomskaia Nia
Исследовался механизм блокирующего действия фенилциклогексильного производного ИЭМ-1925 на ионотропные глутаматные рецепторы NMDA и АМРА типов с использованием метода локальной фиксации потенциала в конфигурации “целая клетка”. ИЭМ-1925 не обладает избирательностью действия на открытые...
Ross Fiziol Zh Im I M Sechenova 92(1): 27-38 (2006); Neurosci Behav Physiol 37(3): 277-84 (2007)
→ glutamate receptors   → channels   → blockade   → rats  
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